Institut für Systembiotechnologie

Welcome at the Institute of Systems Biotechnology

Biotechnology has the potential to revolutionize industrial production - the team headed by Prof. Christoph Wittmann works in the heart of this exciting development. We design and develop cell factories to tailor the synthesis of valuable products - high-end healthcare ingredients, large volume platform chemicals, and smart bio-materials. For this we optimize metabolic pathways and their control in microorganisms and equip them even with new abilities – our leading approaches of systems metabolic engineering and synthetic biology make this possible. Furthermore, we use our "synthetic bugs" to develop innovative, environmentally friendly value chains. The synthesis of the future uses renewable raw materials - we too.

Latest Publications

  • Seo K, Shu W, Rückert-Reed C, Gerlinger P, Erb T, Kalinowski J, Wittmann C (2023)

    From waste to health-supporting molecules: biosynthesis of natural products from lignin-, plastic- and seaweed-based monomers using metabolically engineered Streptomyces lividans.

    Microb. Cell Fact. 22:262. PUBMED.

  • Stegmüller J, Rodríguez Estévez M, Shu W, Gläser L, Myronovskyi M, Rückert C, Kalinowski J, Luzhetskyy A, Wittmann C (2023)

    Systems Metabolic Engineering of Streptomyces albidoflavus at the level of primary and secondary metabolism enhances production of the reverse anitbiotic nybomycin against multi-resistant Staphylococcus aureus.

    Metab. Eng. 81:123-143. PUBMED.

  • Pause L, Weimer A, Wirth NT, Nguyen AV, Lenz C, Kohlstedt M, Wittmann C, Nikel PI, Lai B, Krömer JO (2023)

    Anaerobic glucose uptake in Pseudomonas putida KT2440 in a bioelectrochemical system.

    Microb. Biotechnol. In press. PUBMED.

iSBio News

Saarbrücken biotechnologists conduct research into the production of sustainable recycled...

Nearly 380 million tons of plastics are currently produced each year - with a strong upward trend and the well-known negative consequences for our planet. The EU project "REPurpose" therefore aims...


Novel BMBF-funded project to produce health-promoting omega-3 fatty acids in microbes

Polyunsaturated fatty acids (PUFAs), primarily the marine ones, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have received worldwide attention in recent years due to an increasing...


iSBio to re-program drug producing microbes is featured on the cover of Biotechnology &...

The December 2020 back cover highlights a novel strategy that uses microparticles to streamline the lifestyle of the soil microbe Streptomyces towards elevated production of the antituberculosis...


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