Institut für Systembiotechnologie

Welcome at iSBio

Biotechnology has the potential to revolutionize industrial production - the team headed by Prof. Christoph Wittmann works in the heart of this exciting development. We design and develop cell factories to tailor the synthesis of valuable products - high-end healthcare ingredients, large volume platform chemicals, and smart bio-materials. For this we optimize metabolic pathways and their control in microorganisms and equip them even with new abilities – our leading approaches of systems metabolic engineering and synthetic biology make this possible. Furthermore, we use our "synthetic bugs" to develop innovative, environmentally friendly value chains. The synthesis of the future uses renewable raw materials - we too.

Latest Publications

  • Becker, J, Wittmann, C (2020)

    Microbial production of extremolytes: high-value active ingredients for nutrition, health care and well-being.

    Curr. Opin. Biotechnol. In press.

  • Poblete-Castro, I, Hoffmann, SL, Becker, J, Wittmann, C (2020)

    Cascaded valorization of seaweed using microbial cell factories.

    Curr. Opin. Biotechnol. In press.

  • van Duuren, JBJH, de Wild, PJ, Starck, S, Bradtmöller, C, Selzer, M, Mehlmann, K, Schneider, R, Kohlstedt, M, Poblete-Castro, I, Stolzenberger, J, Barton, N, Fritz, M, Scholl, S, Venus, J, Wittmann, C (2020)

    Limited life cycle and cost assessment for the bioconversion of lignin-derived aromatics into adipic acid

    Biotech. Bioeng. In press.

  • Dolan, S, Kohlstedt, M, Trigg, S, Ramirez, P, Kaminski, C, Wittmann, C, Welch, M (2020)

    Contextual flexibility in Pseudomonas aeruginosa central carbon metabolism during growth in single carbon sources

                                           mBio. In press. PREPRINT.

  • Makowka, A, Nichelmann, L, Schulze, D, Spengler, K, Wittmann, C, Forchhammer, K, Gutekunst, K (2020)

    Glycolytic shunts replenish the Calvin-Benson cycle as anaplerotic reactions in cyanobacteria.

    Mol. Plant. in press.

iSBio News

Christoph Wittmann delivers keynote lecture at MES 2019 in Tianjin

The international ME conference is the world leading conference in the field of metabolic engineering. It brings together leading experts, scientists, and students from industry, the government and academia to present and discuss cutting edge research. Since recent years, ME conferences are backed...


iSBio researchers attend the GIM 2019 conference in Pisa

Five researchers from our iSBio team joined Christoph Wittmann to attend this year’s "International Symposium on the Genetics of Industrial Microbes". The meeting was held from 8th to 11th of July at the conference palace in Pisa, Italy. Over the whole time, GIM 2019 offered an excellent...


Excellent: Best Poster Award for Michael Kohlstedt

Michael Kohlstedt was awarded with the best poster award at the HIPS Symposium, 27-28. July 2019 to highlight his innovative research on the pathogenic bacterium Pseudomonas aeruginosa. Every year in Germany alone, thousands of people die from infections that are caused by this bacterium....


Alle Artikel in der Übersicht

Welcome on board, Jens!

"Hi, my name is Jens Christmann and I have been working as a doctoral student at the iSBio in Saarbrücken since November 2019! Over the past years, I did my studies at the Technical University of Kaiserslautern. After completing a bachelor's degree in the classical field of life sciences, I specialized in the field of biotechnology in the master's program ..."  [more]

This just in!

  Transcriptomics is coming to iSBio

The transcriptome is the complete set of messenger RNA (mRNA) molecules. It displays the set of actively transcribed genes, i.e. the cellular program and actively responds to environmental conditions and genetic modifications. Therefore, transcriptome analysis provides a sensitive readout for fundamental understanding of cellular functions and their optimization... [more]