Institut für Systembiotechnologie

Welcome at iSBio

Biotechnology has the potential to revolutionize industrial production - the team headed by Prof. Christoph Wittmann works in the heart of this exciting development. We design and develop cell factories to tailor the synthesis of valuable products - high-end healthcare ingredients, large volume platform chemicals, and smart bio-materials. For this we optimize metabolic pathways and their control in microorganisms and equip them even with new abilities – our leading approaches of systems metabolic engineering and synthetic biology make this possible. Furthermore, we use our "synthetic bugs" to develop innovative, environmentally friendly value chains. The synthesis of the future uses renewable raw materials - we too.

Latest Publications

  • Becker, J, Wittmann, C (2019)

    Pathways at Work – Metabolic Flux Analysis of the Industrial Cell Factory Corynebacterium glutamicum.

    Microbiol. Monogr. In press.

  • Gießelmann, G, Dietrich, D, Jungmann, L, Kohlstedt, M, Jeon, EJ, Yim, SS, Sommer, F, Zimmer, D, Mühlhaus, T, Schroda, M, Jeong, KJ, Becker, J, Wittmann, C (2019)

    Metabolic engineering of Corynebacterium glutamicum for high-level ectoine production – design, combinatorial assembly and implementation of a transcriptionally balanced heterologous ectoine pathway.

    Biotechnol. J. In press

  • Poblete-Castro, I, Wittmann, C, Nikel, PI (2019)

    Biochemistry, genetics, and biotechnology of glycerol utilization in Pseudomonas species.

    Microb. Biotechnol. PUBMED.

iSBio News

Excellent: Best Poster Award for Michael Kohlstedt

Michael Kohlstedt was awarded with the best poster award at the HIPS Symposium, 27-28. July 2019 to highlight his innovative research on the pathogenic bacterium Pseudomonas aeruginosa. Every year in Germany alone, thousands of people die from infections that are caused by this bacterium....


Judith Becker receives the research price of the Hans-and-Ruth Giessen Foundation

Judith Becker from the Institute of System Biotechnology of Saarland University was awarded the price and 20.000 € for her excellent research on tailor-made cell factories. The patronage of the award ceremony on June 13, 2019 in St. Ingbert had taken over Prime Minister Tobias Hans. In her...


iSBio on TV: Aroma research broadcast in the science magazine Xenius

The ZDF spent a whole day in our laboratories in June to present our research on the fermentation of cocoa beans for its science magazine Xenius. In this way we clarify the basics for the formation of taste in the production of chocolate - in which microorganisms play an important role, as they do...


Alumni Meeting at iSBio - Reunion of more than 20 years of biotechnology research at UdS

On May 10, 2019, there was a warm and euphoric reunion at iSBio. Around 70 former and current employees of the Institutes of Technical Biochemistry and Systems Biotechnology met for a major alumni anniversary. In addition to celebrating more than 20 years of successful biotechnology research and...


Burg Wilenstein – iSBio Retreat

The iSBio team spent three days together at Burg Wilenstein in Rhineland-Palatinate. The castle, a 12th-century hilltop castle, partially restored with a conference center, provided a great ambience for intensive exchange and discussion. Important topics this year were the planning and...


All News

Welcome Julian!

"My name is Julian Stegmüller. I did my Bachelor and Master degree in Biotechnology at the Hochschule Mannheim. Since recently, I am a PhD student at the Institute for Systems Biotechnology. Together with other PhD students, I work on the synthesis of natural products using Streptomycetes ..."  [more]

New face at iSBio

"Hey, my name is Sofija Jovanovic. I obtained my Bachelor Degree in Molecular Biology and Physiology as well as Master Degree in Genetics Engineering and Biotechnology at the University of Belgrade. During my studies in Serbia, I was a bass player in female rock band that had local success in the Balkan area ..."  [more]

Straight from the lab

  New ion chromatography for production

In April, we received a new instrument for the analysis of ions in fermentation samples. Ions play an important role in many of our cell factories and manufacturing processes. They are essential nutrients for cell growth, building blocks for valuable products and regulators of cellular processes ... [more]