Institut für Systembiotechnologie

Welcome at iSBio

Biotechnology has the potential to revolutionize industrial production - the team headed by Prof. Christoph Wittmann works in the heart of this exciting development. We design and develop cell factories to tailor the synthesis of valuable products - high-end healthcare ingredients, large volume platform chemicals, and smart bio-materials. For this we optimize metabolic pathways and their control in microorganisms and equip them even with new abilities – our leading approaches of systems metabolic engineering and synthetic biology make this possible. Furthermore, we use our "synthetic bugs" to develop innovative, environmentally friendly value chains. The synthesis of the future uses renewable raw materials - we too.

Latest Publications

  • Becker, J, Wittmann, C (2019) (2019)

    A field of dreams: Lignin valorization into chemicals, materials, fuels, and health-care products.

    Biotechnol. Adv. in press.

  • Poblete-Castro, I, Wittmann, C, Nikel, PI (2019)

    Biochemistry, genetics, and biotechnology of glycerol utilization in Pseudomonas species.

    Microb. Biotechnol. In press.

  • Kohlstedt, M, Wittmann, C (2019)

    GC-MS based 13C metabolic flux analysis resolves the cyclic glucose metabolism of Pseudomonas putida KT2440 and Pseudomonas aeruginosa PAO1

    Metab. Eng. In press.

iSBio News

New EU project with the French Metabolome platform in Toulouse

The EU initiative IBISBA - Industrial Biotechnology Innovation and Synthetic Biology Accelerator - enables researchers to collaborate transnationally with leading technology platforms to connect top-level biotechnology research within Horizon 2020. Our new project "High Flux" has been selected for...


Metabolic engineering provides new opportunities to improve nutrition and global food security

Since the advent of modern biotechnology, we have experienced a tremendous development, driven and inspired by demand, competition, and the quest for novel, exclusive and sustainable products from renewable resources. Nature itself delivers a diversity of organisms, enzymes, pathways, and metabolic...


All News

New face at iSBio

"My name is Selma Beganovic. I recently joined iSBio to work as a PhD student to become in a project team, which is dedicated to systems metabolic engineering of microbes of the genus Streptomyces, producers of natural compounds with applications in human health and well-being. Personally, I feel that these endeavors are particularly relevant in light of the struggle of human mankind a constant increasing antibiotic resistance. My own efforts are directed towards developing superior producers of S. rimosus, an industrial strain for oxytetracycline production. Being a part of a team, which is setting a milestone in production of novel bioactive compounds extremely inspirational and motivational for me. I feel very grateful to my new colleagues in making acclimatization to this new stage in my professional career so smooth and pleasant. It is great to be be part of iSBio."

Selma Beganovic has graduated in Molecular and Plant Biotechnology at TU Kaiserslautern. Since October 2018, Selma is a PhD student in the European project "MISSION", funded within the ERANET initiative CoBioTech and works on systems biology and systems metabolic engineering of Streptomyces rimosus.